Synergistic Effect of Ionizing Radiation and β-lapachone against RKO Human Colon Adenocarcinoma Cells
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چکیده
منابع مشابه
Primula auriculata Extracts Exert Cytotoxic and Apoptotic Effects against HT-29 Human Colon Adenocarcinoma Cells
Primula auriculata (Tootia) is one of the most important local medicinal plants in Hamedan district, Iran. To investigate cytotoxicity and apoptosis induction of crude methanolic extract and different fraction of it we compared several methods on HT-29 human colon Adenocarcinoma cells. Cancer cell proliferation was measured by 3-(4, 5‑dimethylthiazolyl)-2, 5‑diphenyl‑tetrazolium bromide (MTT) a...
متن کاملPrimula auriculata Extracts Exert Cytotoxic and Apoptotic Effects against HT-29 Human Colon Adenocarcinoma Cells
Primula auriculata (Tootia) is one of the most important local medicinal plants in Hamedan district, Iran. To investigate cytotoxicity and apoptosis induction of crude methanolic extract and different fraction of it we compared several methods on HT-29 human colon Adenocarcinoma cells. Cancer cell proliferation was measured by 3-(4, 5‑dimethylthiazolyl)-2, 5‑diphenyl‑tetrazolium bromide (MTT) a...
متن کاملβ-Lapachone Significantly Increases the Effect of Ionizing Radiation to Cause Mitochondrial Apoptosis via JNK Activation in Cancer Cells
BACKGROUND β-lapachone (β-lap), has been known to cause NQO1-dependnet death in cancer cells and sensitize cancer cells to ionizing radiation (IR). We investigated the mechanisms underlying the radiosensitization caused by β-lap. METHODOLOGY/PRINCIPAL FINDINGS β-lap enhanced the effect of IR to cause clonogenic cells in NQO1(+)-MDA-MB-231 cells but not in NQO1(-)-MDA-MB-231 cells. β-lap cause...
متن کاملSynergistic E ffect of Ionizing Radiation and β-lapachone against RK O H um an C olon A denocarcinom a C ells
Eun Jung Kim, In-Mi Ji, Ki-Jung Ahn, M.D., Eun Kyung Choi, M.D., Ph.D., Heon-Jin Park, Ph.D., Byung Uk Lim, M.D., Ph.D., Chang W. Song, Ph.D. and Heon Joo Park, M.D., Ph.D. Department of Microbiology, College of Medicine, Inha University, Incheon, Korea, Department of Therapeutic Radiology, College of Medicine, University of Ulsan, Seoul, Korea, Department of Statistics College of Medicine, Inh...
متن کاملβ,β-Dimethylacrylshikonin sensitizes human colon cancer cells to ionizing radiation through the upregulation of reactive oxygen species
Shikonin, a naphthoquinone derivative, has been shown to possess antitumor activity. In the present study, the effects of shikonin and its analog, β,β-dimethylacrylshikonin, were investigated as radiosensitizers on the human colon cancer cell line, HCT-116. Shikonin and, to a greater extent, its analog-induced apoptosis of HCT-116 cells further synergistically potentiated the induction of apopt...
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ژورنال
عنوان ژورنال: Cancer Research and Treatment
سال: 2005
ISSN: 1598-2998
DOI: 10.4143/crt.2005.37.3.183